Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling.
E. Nicholas Petersen, Mahmud Arif Pavel, Samuel S. Hansen, Manasa V. Gudheti, Hao Wang, Zixuan Yuan, Keith R. Murphy, William W. Ja, Heather Anne Ferris, Erik M. Jørgensen, Scott B. Hansen
The paper shows mechanical force activates TREK-1 channels via PLD2 and lipid clustering, leading to second messenger signaling and ion flow.
bioRxiv · Oct 16, 2023 · PreprintNeuroscience