FragLite mapping to identify the BRD4 recruitment site of P-TEFb
Ian Hope, Richard Heath, Arnaud Baslé, Mathew P. Martin, Michael J. Waring, Jane Endicott, Martin E. M. Noble, Natalie J. Tatum
The paper uses FragLites to map BRD4 recruitment sites on cyclin T2, revealing interactions with CDK9, AFF4, and HIV-1 Tat, and integrates this with biophysical and AlphaFold3 analyses to define the cyclin T-BRD4 interface.
bioRxiv · Apr 12, 2026 · PreprintBiophysics