Ian Hope

FragLite mapping to identify the BRD4 recruitment site of P-TEFb

The paper uses FragLites to map BRD4 recruitment sites on cyclin T2, revealing interactions with CDK9, AFF4, and HIV-1 Tat, and integrates this with biophysical and AlphaFold3 analyses to define the cyclin T-BRD4 interface.

Crystallographic fragment screening of CDK2-cyclin A: FragLites map sites of protein-protein interaction

The paper uses X-ray crystallographic screening with FragLite to map protein-protein interaction sites on CDK2-cyclin A, identifying known and potential new interaction sites.