Endothelial deletion of ADGRF5 (GPR116) promotes fibro-inflammatory EndMT and impairs adaptive thermogenesis in brown adipose tissue
Rabih El‐Merahbi, Vasiliki Karagiannakou, Ronja Kardinal, Lea Seep, Richard Lindner, Michelle Y. Jaeckstein, Staffan Hildebrand, Mersiha Hasić, Eylül Korkmaz, Ankush Kumar Jha, Aspasia Thodou Krokidi, Kenneth Allen Dyar, Felix Meissner, Stephan Grein, Jörg Heeren, , Anastasia Georgiadi
This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.
Molecular Metabolism · Mar 7, 2026Peer-reviewedMolecular Biology