A molecular and spinal circuit basis for the functional segregation of itch and pain
Myung‐chul Noh, Kelly A. Corrigan, Sean-Paul G. Williams, Cédric Peirs, Michael J. Leone, Daniel J. Headrick, Mustafa Guvercin, Suhjin Lee, BaDoi N. Phan, Xinyi Zhao, David A. Henry, Deepika Yeramosu, Sudhagar Babu, Ashley R. Brown, Robert van de Weerd, , Rebecca P. Seal
The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.
Neuron · Sep 1, 2026Peer-reviewedNeuroscience