Alexander G. Chamessian

Inducible Calling Cards: Developing Mouse Reagents for Experimentally Controlled Transposon Insertion in vivo.

This paper develops inducible Calling Cards in mice to control transposon insertion timing in vivo, showing varying efficacy and developmental impacts based on the transcription factor used.

A multi-omic atlas of human autonomic and sensory ganglia implicates cell types in peripheral neuropathies

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

Single nucleus multi-omic atlas of human dorsal root ganglia reveals the contribution of nonneuronal cell types to pain

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective Behaviors

The paper identifies CeA neuronal ensembles that modulate visceral pain and its affective behaviors through optogenetic manipulation and single-nucleus RNA sequencing.

Multimodal profiling of human sensory neurons links electrical properties to transcriptional identity

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

Expression of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Human Peripheral Nervous System: Implications for the Putative Pathogenic Role of FGFR3 Autoantibodies in Neuropathy

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

Small molecule-mediated targeted protein degradation of voltage-gated sodium channels involved in pain

This study investigates the use of small molecule degraders to target voltage-gated sodium channels NaV1.8 and NaV1.7, showing their degradation via PROTACs and molecular glues involving CRBN and VHL.

Spatial, transcriptomic and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition

The paper links chronic pain genetic variants to dorsal horn neuron subtypes using multi-species single-cell and spatial transcriptomic analyses.

Microglial refinement of A-fibre projections in the postnatal spinal cord dorsal horn is required for normal maturation of dynamic touch.

This study shows that microglia phagocytose A-fibre terminals in the spinal cord dorsal horn during postnatal development, and their absence leads to hypersensitivity to dynamic touch.

Profiling the molecular signature of Satellite Glial Cells at the single cell level reveals high similarities between rodent and human

The paper characterizes the transcriptional profile of Satellite Glial Cells (SGC) in mouse, rat, and human at the single-cell level, finding conserved key features across species.

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn

The paper identifies the transcriptomic profile of somatostatin-expressing interneurons in the spinal dorsal horn of mice, revealing novel genes and pathways relevant to mechanical pain.