Cédric Peirs

This study identifies a previously dormant neuronal circuit in the spinal dorsal horn that becomes active in neuropathic pain, leading to mechanical allodynia.

The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.

This study shows nerve injury shifts spinal circuit recruitment from inhibitory to excitatory parvalbumin interneurons, causing mechanical allodynia.

This study identifies spinal oxytocin circuits as a conserved mechanism through which affiliative touch reduces pain and enhances well-being in mice and humans.