Rebecca P. Seal

This paper demonstrates noninvasive, focal gene delivery to the primate spinal cord using focused ultrasound, showing functional transgene expression and preserved neurological function.

The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

The paper creates a cross-species spinal cord cell type atlas integrating data from mouse, macaque, and human, identifying conserved and species-specific features.

This paper identifies cell-type-specific genetic variants associated with chronic pain using GWAS and scRNA-seq data from brain and dorsal root ganglia tissues.

The paper develops a platform combining machine learning and multiplexed in situ screening to identify enhancers with cell-type and behavioral specificity for neural circuit engineering.

The paper links chronic pain genetic variants to dorsal horn neuron subtypes using multi-species single-cell and spatial transcriptomic analyses.

The paper compares topographic precision of ipsilateral and contralateral cortical projections in frontal, motor, and somatosensory areas of mice, finding stronger contralateral projections in frontal regions.

The paper shows that temporarily increasing dopamine in a Parkinson's mouse model preserves motor function, neuron structure, and specific neural inputs.

This study identifies a striatal plasticity mechanism that delays motor deficits in a Parkinsonian mouse model by preserving direct pathway connectivity through transient dopamine neuron activity elevation.