Robert van de Weerd

A molecular and spinal circuit basis for the functional segregation of itch and pain

The paper identifies functionally distinct subtypes within Grpr+ neurons in the dorsal horn that mediate itch and mechanical allodynia, demonstrating the utility of genomic enhancer-based strategies for modality-specific targeting.

Context-dependent regulatory variants in Alzheimer's disease

The paper identifies context-dependent regulatory variants in Alzheimer's disease by analyzing their effects across different cellular contexts using MPRAs and machine learning.

Combining Machine Learning and Multiplexed, In Situ Profiling to Engineer Cell Type and Behavioral Specificity

The paper develops a platform combining machine learning and multiplexed in situ screening to identify enhancers with cell-type and behavioral specificity for neural circuit engineering.

An in vivo massively parallel platform for deciphering tissue-specific regulatory function

The paper introduces WhAMPRA, an in vivo MPRA platform in mice, to assess tissue-specific regulatory functions of genetic variants and enhancers.

Biofilm dispersal patterns revealed using far-red fluorogenic probes

This study uses far-red fluorogenic probes to reveal single-cell dispersal patterns in Vibrio cholerae biofilms, showing that dispersal starts at the periphery and 25% of cells never disperse.