GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior
Chihiro Nakamoto, Meiko Kawamura, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Masahiko Watanabe, Manabu Abe, Tomonori Takeuchi, Kenji Sakimura
This study shows that GluD1 knockout mice exhibit impaired fear memory, reduced sociability, and enhanced depressive-like behavior, with antidepressant effects observed with serotonin reuptake inhibitors.
PLoS ONE · Feb 20, 2020Peer-reviewedNeuroscience