Michael J. Higley

The paper investigates how cholinergic and adrenergic modulation differentially regulate inhibitory inputs from PV- and VIP interneurons onto SST-INs in visual cortex.

This study shows that multivesicular release dominates synaptic transmission in vivo, enhancing reliability and enabling non-binary signaling at single synapses.

This paper introduces SSLD, a framework that learns shared neural-behavioral latent dynamics and private modality-specific variables, showing it accurately reconstructs signals and isolates behaviorally relevant information across multiple datasets.

This study shows that visual fear conditioning leads to ACh release in visual cortex, enhancing neuronal responses and facilitating learned behavior.

The paper examines the developmental trajectory of somatostatin interneurons in the mouse visual cortex, showing their increasing influence on pyramidal neuron responses over time.

This study identifies excitatory synapses as primary targets of α-synuclein aggregation in a Parkinson's disease mouse model, revealing spatial and temporal patterns of synaptic vulnerability.

This study shows that traumatic brain injury disrupts functional connectivity in mice, with recovery and state-dependent changes in connectivity and theta power during stillness.

The paper introduces a long working distance air objective for multiphoton imaging in vivo, demonstrating its performance across multiple species and imaging systems.

This study shows that the medial entorhinal cortex encodes visual cues through distinct neuronal populations, and retrosplenial inputs are critical for this sensory representation.

The paper uses dual-color mesoscopic imaging in awake mice to show that cholinergic and cortical activity are spatiotemporally heterogeneous and linked to behavioral states.

This study uses calcium imaging in awake mice to show that rapid changes in cortical functional connectivity encode spontaneous behaviors and reveal subnetworks not captured by traditional parcellation.

This study shows that V1 neurons in mice encode visual stimuli and behavioral representations during learning, with NMDARs required for behavioral representation plasticity.

The paper shows that tonic GABAergic activity via low-affinity GABAARs boosts dendritic calcium signaling and modulates short-term synaptic plasticity.

The paper shows that layer 5 corticopontine neurons in V1 are essential for visual detection tasks, suggesting functionally segregated cortical networks control behavior.

The paper develops a method to simultaneously image local microcircuits and whole cortical activity in awake mice, and uses it to study neuron associations with network motifs.

This study shows that ketamine reduces RGS4 expression, disrupting neuromodulatory control of glutamatergic synapses in the prefrontal cortex of mice.

This paper combines mesoscopic Ca2+ imaging and fMRI to study brain activity across spatiotemporal scales, finding correspondence between signals and stable connectivity matrices.

The paper shows voltage-gated potassium channels suppress GABAergic inhibition in dendrites but are inactivated by activity, enhancing inhibition and limiting calcium influx.

The paper shows that NMDAR activation leads to input-specific potentiation of dendritic GABAergic inhibition via somatostatin interneurons, requiring CaMKII and GABA-A β2-subunit, and highlights its role in maintaining synaptic balance.