Manabu Abe

Asymmetric turnover dynamics of Nav1.6 voltage-gated sodium channels at the axon initial segment

The paper uses a genetically engineered mouse to study Nav1.6 sodium channel turnover dynamics at the axon initial segment, revealing spatially asymmetric turnover and its role in AIS quality control.

High basal autophagic activity in the brain revealed by systemic quantitative analysis using GFP-LC3-RFP mice

This study quantifies basal autophagic flux in mice using GFP-LC3-RFP reporter mice, revealing higher flux in brain, liver, and kidney compared to other tissues.

A Knock-In Igfn1iCre transgenic mouse line provides partial developmental access to type-7 bipolar cells

The paper generates an Igfn1iCre knock-in mouse line to study type-7 bipolar cells during development and confirms Igfn1 expression in these cells and other retinal types.

KEAP1 retention in phase-separated p62 bodies drives liver damage in autophagy-deficient conditions

The paper shows that KEAP1 retention in p62 bodies and NRF2 activation cause liver damage when autophagy is impaired, and that blocking p62-KEAP1 interactions reduces this damage.

Visualization of stochastic expression of clustered protocadherin β isoforms in vivo

The paper develops cPcdhβ reporter mouse lines to visualize stochastic expression of cPcdhβ isoforms in vivo and identifies patterns such as cell-type selectivity and developmental regulation.

AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons

This study identifies AUTS2's role in regulating intermediate progenitor cell division and upper-layer neuron production through interaction with PRC2 and repression of genes like Robo1.

Brn3a controls the soma localization and axonal extension patterns of developing spinal dorsal horn neurons

This study shows that Brn3a controls soma localization and axonal extension patterns in spinal dorsal horn neurons by analyzing its expression and effects in mice.

Neurexins in serotonergic neurons regulate serotonin transmission and complex mouse behaviors

This study shows that disrupting Neurexins in serotonergic neurons reduces serotonin release and alters behavior in mice.

Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins

This study shows that Neurexins are essential for cerebellar granule cell survival by organizing autocrine neurotrophin secretion machinery, independent of postsynaptic contact.

Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum

This study identifies astrocyte GluN2C NMDARs as regulators of basal synaptic strength distribution in hippocampal CA1 pyramidal neurons, specifically in stratum radiatum inputs.

A Specific Neuroligin3-αNeurexin1 Code Regulates GABAergic Synaptic Function in Mouse Hippocampus

The paper shows that Nlgn3 interacts with Nrxn1+AS4 in inhibitory synapses to regulate synaptic transmission in mouse hippocampus.

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

This study investigates the role of AUTS2 in cerebellar development, Purkinje cell maturation, and behavioral functions, finding that its loss leads to cerebellar defects and behavioral impairments linked to ASDs.

AUTS2 regulation of synapses for proper synaptic inputs and social communication.

This study shows that AUTS2 regulates excitatory synapse number to maintain E/I balance, and its loss leads to autistic-like behaviors and increased brain excitability.

GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior

This study shows that GluD1 knockout mice exhibit impaired fear memory, reduced sociability, and enhanced depressive-like behavior, with antidepressant effects observed with serotonin reuptake inhibitors.

Dissociating orexin-dependent and -independent functions of orexin neurons using novel orexin-Flp knock-in mice

This study uses orexin-Flp knock-in mice to distinguish orexin-dependent and -independent functions of orexin neurons, finding orexin is essential for sustained arousal and basic neuronal properties.

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice

This study identifies VTAGad67+ GABAergic neurons as key regulators of NREM sleep in mice through chemogenetic and optogenetic manipulations and electrophysiological recordings.