Single-Nuclei Transcriptomic Characterization of APOE4-Associated Alzheimer's Disease
Kaitlin E. Murtha, Anjalika Chongtham, W-m Song, Marjan Ilkov, Minghui Wang, Catherine Qing Chen, Claudia De Sanctis, Risit Datta, Dushyant P. Purohit, Edward B. Lee, Bin Zhang, Ana C. Pereira
This study characterizes cell-type-specific transcriptomes across APOE genotypes in Alzheimer's disease using single-nuclei RNA sequencing, revealing APOE4-associated changes in excitatory neurons and microglia.
bioRxiv · Apr 4, 2026 · PreprintNeuroscience