Anjalika Chongtham

This study characterizes cell-type-specific transcriptomes across APOE genotypes in Alzheimer's disease using single-nuclei RNA sequencing, revealing APOE4-associated changes in excitatory neurons and microglia.

The paper uses Nanopore long-read DNA sequencing to analyze retrotransposon activation in aged and Alzheimer's disease brains, identifying somatic insertions and epigenetic changes.

This study shows that gut bacteria influence Huntington's disease progression in Drosophila models, with antibiotics and compounds like crocin reducing disease symptoms while E. coli worsens them.

This study shows sonicated HTTex1 fibrils selectively seed neurons, leading to toxic assemblies and neuronal damage.