Kaitlin E. Murtha

This study shows that lack of oncomodulin in adult mice increases ATP-dependent calcium signaling and susceptibility to noise-induced hearing loss.

This study characterizes cell-type-specific transcriptomes across APOE genotypes in Alzheimer's disease using single-nuclei RNA sequencing, revealing APOE4-associated changes in excitatory neurons and microglia.

This study shows that Oncomodulin modulates spontaneous calcium signaling and afferent innervation maturation in cochlear outer hair cells during development.

This study shows that OCM uniquely regulates intracellular Ca2+ signaling in neonatal cochlear outer hair cells by slowing Ca2+ kinetics and reducing free [Ca2+]i.

This study shows that Oncomodulin prevents early progressive hearing loss in C57 and CBA mice by maintaining Ca2+ signaling in outer hair cells.