Marjan Ilkov

Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

This study shows that nonfibrillar Aβ aggregates in APPE693Q mice disrupt presynaptic function without causing inflammation.

Single-Nuclei Transcriptomic Characterization of APOE4-Associated Alzheimer's Disease

This study characterizes cell-type-specific transcriptomes across APOE genotypes in Alzheimer's disease using single-nuclei RNA sequencing, revealing APOE4-associated changes in excitatory neurons and microglia.

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

The paper identifies novel genetic loci associated with blood pressure that interact with sleep duration across multiple ancestries.

Deep serum proteomics reveal biomarkers and causal candidates for type 2 diabetes

This study uses deep serum proteomics to identify 20 protein biomarkers for predicting type 2 diabetes and finds 48 proteins with causal roles in its development.

Coding and regulatory variants affect serum protein levels and common disease

The paper identifies 2019 exome array variants affecting 2135 serum proteins and their association with hundreds of complex disease traits in the AGES Reykjavik cohort.

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.