Cancer BiologyCell chemical biologyPeer-reviewed
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
Anna Shemorry, Willem den Besten, Melinda M. Mulvihill…·Ingrid E. Wertz
This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.
1 citation