Author

Danilo Maddalo

GenentechORCID 0000-0002-3228-1703Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Frank Peale· 2 shared Abbas NaziriD· 1 shared Anna ShemorryiD· 1 shared Aviv RegeviD· 1 shared Bence DánieliD· 1 shared Carrie R. GraveeliD· 1 shared Curt J. EssenburgiD· 1 shared Elisia VillemureiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Frank Peale

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 22, 2026

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancer

Abbas Nazir, Hanchen Wang, Ziyu Lu…·Aviv Regev

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

DOI 10.64898/2026.04.19.719485

mousescRNA-seq

𝕏 PostBluesky

Cancer BiologyCell chemical biologyPeer-reviewedMay 1, 2025

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

Anna Shemorry, Willem den Besten, Melinda M. Mulvihill…·Ingrid E. Wertz

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

1 citation

humanproteomics

𝕏 PostBluesky