Author

Ingrid E. Wertz

Bristol-Myers Squibb (United States)ORCID 0000-0002-7979-9374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andres H. de la PeñaiD· 1 shared Anna ShemorryiD· 1 shared Carrie R. GraveeliD· 1 shared Curt J. EssenburgiD· 1 shared Danilo MaddaloiD· 1 shared Edmond R. WatsoniD· 1 shared Eileen TraniD· 1 shared Elisia VillemureiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Andres H. de la PeñaORCID

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2 papers

Recent·Most cited

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

Anna Shemorry, Willem den Besten, Melinda M. Mulvihill, Curt J. Essenburg, Nicole Blaquière, Tracy Kleinheinz, Elisia Villemure, Frank Peale, Gauri S. Deshmukh, Danilo Maddalo, Elizabeth Levy, Kebing Yu, Matthew R. Steensma, Elizabeth A. Tovar, Emily Wolfrum, , Ingrid E. Wertz

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

Cell chemical biology · May 1, 2025Peer-reviewedCancer Biology

Molecular glue CELMoD compounds are allosteric regulators of cereblon conformation

Edmond R. Watson, Scott J. Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres H. de la Peña, Jin‐Yi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander

This study investigates how CELMoD compounds induce conformational changes in cereblon, enabling neosubstrate binding and informing drug design strategies.

bioRxiv · Jul 2, 2022 · PreprintMolecular Biology