Author
Amgen (United States)
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Jianzhong Hu, Weixian Deng, Shu Ou…·Jaeki Min
This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.
Anna Shemorry, Willem den Besten, Melinda M. Mulvihill…·Ingrid E. Wertz
This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.
Jonathan W. Bushman, Weixian Deng, Kusal T. G. Samarasinghe…·Patrick Ryan Potts
The paper discovers a VHL molecular glue degrader of GEMIN3 using Picowell RNA-seq screening, showing how it targets GEMIN3 for degradation through ternary complex formation.
Senthil K Radhakrishnan, Willem den Besten, Raymond J Deshaies
The paper shows that p97-dependent retrotranslocation and proteolytic processing of Nrf1 are essential for its activation upon proteasome inhibition.