Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production
Julie S. Valastyan, Emilee E. Shine, Robert A. Mook, Bonnie L. Bassler
This study identifies PqsR inhibitors that reveal RhlR's dependence on PqsE for pyocyanin biosynthesis, suggesting PqsR inhibition as a therapeutic strategy against Pseudomonas aeruginosa.
ACS Chemical Biology · May 14, 2025Peer-reviewedMicrobiology