Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells
Giulio Vidotto, Sara Luzzi, Jonathan D. Humphries, Robert Beal, David G. McVey, Christopher P. Nelson, Tom R. Webb, Martin James Humphries, Graham R. Smith, Stephen J. White
This study identifies distinct gene expression changes in human coronary artery endothelial cells under elevated flow compared to oscillatory and normal flow, highlighting unique regulatory effects on CAD-related pathways and alternative splicing.
Journal of the American Heart Association · Jun 23, 2026Peer-reviewedCell Biology