Jonathan D. Humphries

This study shows that PDLIM5 regulates YAP1 localization and fibrogenic gene expression in hepatic stellate cells through mechanical cues.

This study identifies distinct gene expression changes in human coronary artery endothelial cells under elevated flow compared to oscillatory and normal flow, highlighting unique regulatory effects on CAD-related pathways and alternative splicing.

This study identifies KANK2 and talin2 in reticular adhesions of melanoma cell lines and shows their differential roles in RA composition.

This study shows KANK2 has distinct roles in focal adhesions and fibrillar adhesions, regulating their maintenance and cell migration via microtubule interactions.

The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.

The paper identifies hypoxia-induced ECM changes across cancers and shows they predict radiotherapy benefit.