Martin James Humphries

Co-translational O-glycosylation driven by GALNTs spatial reprogramming fosters pancreatic cancer growth

The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells

This study identifies distinct gene expression changes in human coronary artery endothelial cells under elevated flow compared to oscillatory and normal flow, highlighting unique regulatory effects on CAD-related pathways and alternative splicing.

Manchester Proteome Profiler: A User-Friendly Platform for Quantitative Proteomic Analysis

The paper introduces MPP, a user-friendly R Shiny platform for quantitative proteomic analysis, demonstrating its ability to identify reproducible clusters and reveal biologically meaningful patterns.

Regulation of reticular adhesions by KANK2 and talin2 in two melanoma cell lines

This study identifies KANK2 and talin2 in reticular adhesions of melanoma cell lines and shows their differential roles in RA composition.

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

This study shows KANK2 has distinct roles in focal adhesions and fibrillar adhesions, regulating their maintenance and cell migration via microtubule interactions.

A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

The paper identifies a TRPV4-dependent Ca2+ signaling pathway that regulates lamellipodia actin architecture and promotes cell migration through RhoA and formin-mediated actin assembly.

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

This study identifies PRPF8 as essential for left-right organiser cilia function and cardiac asymmetry by regulating ARL13B splicing in mice and zebrafish.

Inhibitory TIGIT signalling is dependent on T cell receptor activation

The paper identifies TIGIT interactors and shows that inhibitory TIGIT signaling requires both CD155 ligation and TCR activation in T cells.

Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit

The paper identifies hypoxia-induced ECM changes across cancers and shows they predict radiotherapy benefit.

Eps8 is a convergence point integrating EGFR and integrin trafficking and crosstalk

This study identifies Eps8 as a key integrator of EGFR and integrin trafficking, showing it regulates their endocytosis and adhesion complex dynamics.

Improved LC-MS chromatographic alignment increases the accuracy of label-free quantitative proteomics: Comparison of spectral counting versus ion intensity-based proteomic quantification strategies.