David G. McVey

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells

This study identifies distinct gene expression changes in human coronary artery endothelial cells under elevated flow compared to oscillatory and normal flow, highlighting unique regulatory effects on CAD-related pathways and alternative splicing.

Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments Profiling

This study identifies genetic determinants of endothelial cell molecular traits and their overlap with disease GWAS loci, revealing shared and unique mechanisms in non-communicable diseases.

Allele-specific epigenetic regulation of FURIN expression at a coronary artery disease susceptibility locus

This study shows that the coronary artery disease variant rs17514846 affects FURIN expression through allele-specific DNA methylation and MeCP2 binding in monocytes.

Identification and Characterization of novel long non-coding RNAs in vascular smooth cells

The paper identifies and characterizes 329 novel long non-coding RNAs in vascular smooth muscle cells, finding they are mostly antisense transcripts with cytoplasmic localization and miRNA targets.