The structural basis for LRRK2's activation and autoinhibition
Amalia C. Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug, Wei Gai, Katherine J. Surridge, Elizabeth Moussikhina, Kendrick H V Nguyen, Marta M. Sanz Murillo, Robert Callahan, Erica Xiong, Delisa Ramos, Lawrence Zhu, Verena Dederer, Sebastian Mathea, Janet Iwasa, , Andrés E. Leschziner
This paper elucidates the structural mechanisms by which LRRK2 is activated and autoinhibited, showing how mutations affect these processes and suggesting therapeutic strategies.
Cell · Aug 10, 2026Peer-reviewedNeuroscience