Author
University of California San DiegoORCID 0009-0000-1928-6991Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Amalia C. Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug…·Andrés E. Leschziner
This paper elucidates the structural mechanisms by which LRRK2 is activated and autoinhibited, showing how mutations affect these processes and suggesting therapeutic strategies.
Kendrick H V Nguyen, Eva Pauline Karasmanis, Agnieszka A. Kendrick…·Andrés E. Leschziner
The paper uses cryo-EM to identify an early intermediate state in dynein activation by LIS1, termed Pre-Chi, and shows its functional importance through mutational analysis.
Agnieszka A. Kendrick, Kendrick H V Nguyen, Wen Ma…·Andrés E. Leschziner
The paper uses cryo-EM to visualize intermediate states of dynein activation pathway by analyzing structures of dynein and dynein-Lis1 bound to ATP.