Author

Amalia C. Villagran Suarez

University of California San DiegoORCID 0000-0003-3400-2330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andrés E. LeschzineriD· 2 shared Erica XiongiD· 2 shared Marta M. Sanz MurilloiD· 2 shared Delisa RamosiD· 1 shared Elizabeth MoussikhinaiD· 1 shared Elizabeth VillaiD· 1 shared Jaime Alegrio LouroiD· 1 shared Janet IwasaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Andrés E. LeschzinerORCID

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2 papers

Recent·Most cited

NeuroscienceCellPeer-reviewedAug 10, 2026

The structural basis for LRRK2's activation and autoinhibition

Amalia C. Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug…·Andrés E. Leschziner

This paper elucidates the structural mechanisms by which LRRK2 is activated and autoinhibited, showing how mutations affect these processes and suggesting therapeutic strategies.

3 citationstop 1%

experimental assay

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BiophysicseLifePeer-reviewedSep 9, 2024

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

Siyu Chen, Tamar Basiashvili, Joshua Hutchings…·Elizabeth Villa

This study uses cryo-ET to show that LRRK2 can form microtubule-bound filaments in its autoinhibited state, with structural differences compared to active-LRRK2 filaments.

12 citations

humancryo-EM

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