Time-resolved structures of β2-adrenergic receptor modulation by a photoswitchable beta-blocker
Robin Stipp, Quentin Bertrand, Matilde Cardoso Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans Peter Seidel, Matthias Mulder, Thomas J. Mason, Yasushi Kondo, Maximilian Wranik, , J. Standfuss
This study captures time-resolved structures of β2AR modulated by a photoswitchable beta-blocker, revealing conformational changes linked to ligand isomerization and receptor function.
bioRxiv · Sep 3, 2025 · PreprintBiochemistry