Molly E. Klug

Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems

The paper maps transsynaptic circuits of ventral hippocampus neurons projecting to motivational control regions in rats using viral tracing methods.

Consumption of processed foods impairs memory function through dietary advanced glycation end-products

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

A ventral hippocampus to nucleus accumbens pathway regulates impulsivity

This study identifies a hippocampal-striatal circuit that regulates impulsive action in male rats, using chemogenetic and fiber photometry approaches.

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake

This study shows that oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei have opposing effects on food intake, with PVH neurons reducing meal size and SON neurons increasing it.

The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction

This study shows that vagus nerve-mediated acetylcholine release in the dorsal hippocampus supports memory function, and its disruption contributes to obesity-induced cognitive impairments.

Ventral hippocampus neurons encode meal-related memory

The paper identifies ventral hippocampus neurons that encode meal-related memories and shows their role in spatial memory and feeding behavior.

Endotoxemia-induced inflammation in the absence of obesity decreases anxiety-like and impulsive behavior without affecting learning and memory

This study shows that endotoxemia-induced inflammation without obesity reduces anxiety-like and impulsive behavior but does not impair learning and memory in rats.

ATLAS: A rationally designed anterograde transsynaptic tracer

The paper introduces ATLAS, an anterograde transsynaptic tracer based on an antibody-like protein, which enables non-toxic, synaptic, and activity-dependent circuit tracing in vivo and in dissociated cultures.

Western diet consumption impairs memory function via dysregulated hippocampus acetylcholine signaling

This study shows that a western diet during development impairs memory by disrupting hippocampal acetylcholine signaling, which can be partially reversed with pharmacological intervention.

Hippocampus oxytocin signaling promotes prosocial eating in rats

This study shows that oxytocin signaling in the dorsal hippocampus promotes prosocial eating in rats by enhancing food consumption with familiar conspecifics and facilitating social transmission of food preference.

Ventral hippocampus-lateral septum circuitry promotes foraging-related memory

This study identifies a neural circuit involving the ventral hippocampus and lateral septum that selectively mediates appetitive spatial memory for food or water locations.