Intracellular pathogen targeting by IL32 elicits cell-autonomous immunity
Jeffrey R. Reitano, Stephen C. Walsh, Mary S Dickinson, Emma Anne Johnston, María E. Cortina, Haley E. Adcox, Neal M. Alto, Isabelle Derré, Kevin Hybiske, Robert J. Suchland, So Young Kim, Jörn Coers
The paper identifies IL32 as a cytokine that targets intracellular pathogens via the N-degron pathway and autophagy, revealing a mechanism by which IFN-gamma signaling mediates host defense against pathogens like Chlamydia.
bioRxiv · Jul 25, 2026 · PreprintImmunology