Jörn Coers

The paper identifies IL32 as a cytokine that targets intracellular pathogens via the N-degron pathway and autophagy, revealing a mechanism by which IFN-gamma signaling mediates host defense against pathogens like Chlamydia.

This study shows that GBPs balance iNOS and ARG-1 in myeloid cells to control Leishmania major infection, with GBPChr3 knockout mice showing increased parasite load and disease severity.

This study identifies GVIN1 as an IFNg-inducible host defense protein that blocks Burkholderia thailandensis from using actin polymerization for motility by forming a coatomer that displaces BimA.

This study identifies IpaH1.4 as a Shigella effector that degrades RNF213, preventing ubiquitylation of intracellular bacteria and evading host immunity.