Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies
Matthias Schmidt, Namil Lee, Chunjun Zhan, Jacob B. Roberts, Alberto A. Nava, Leah S. Keiser, Aaron A. Vilchez, Yan Chen, Christopher J. Petzold, Robert W. Haushalter, Lars M. Blank, Jay D. Keasling
This study evaluates codon optimization strategies for improving heterologous expression of engineered type I polyketide synthases in three bacterial hosts and develops an online tool for codon optimization.
ACS Synthetic Biology · Oct 18, 2023Peer-reviewedSynthetic Biology