This study develops a once-monthly dosing form of semaglutide using hydrogel microspheres, showing equivalent weight loss to daily dosing in mice and simulating human efficacy.

Proceedings of the National Academy of Sciences · Nov 12, 2024Peer-reviewedBioengineering

Releasable hydrogel microsphere-drug conjugates as generic prodrugs for long-acting intra-tumoral therapy

Jeff Henise, John A. Hangasky, Deborah H. Charych, Christopher W. Carreras, Gary W. Ashley, Daniel V. Santi

This paper develops hydrogel microsphere-drug conjugates for long-acting intra-tumoral therapy, showing improved efficacy and reduced toxicity compared to systemic delivery.

Scientific Reports · Jun 18, 2024Peer-reviewedCancer Biology

An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism

Mitchell G. Thompson, Jacquelyn M. Blake-Hedges, Jose Henrique Pereira, John A. Hangasky, Michael S. Belcher, William M. Moore, Jesus F. Barajas, Pablo Cruz‐Morales, Lorenzo J. Washington, Robert W. Haushalter, Christopher B. Eiben, Yuzhong Liu, Will Skyrud, Veronica Teixeira Benites, Tyler P. Barnum, , Jay D. Keasling

The paper identifies an iron-dependent enzyme in plants that completes the lysine catabolism pathway, showing structural and functional conservation across species.

Nature Communications · Jun 10, 2020Peer-reviewedMolecular Biology