Mechanical Tension Actively Triggers RhoA-Mediated Cell Extrusion
Fanny Wodrascka, Tianxiang Ma, Pablo Gottheil, Robin Durand, Lucas Anger, Andreas Schoenit, Mallica Pandya, M Arnaud, Tien Dang, Siavash Monfared, Guillaume Charras, René‐Marc Mège, Amin Doostmohammadi, Benoît Ladoux, Simon de Beco
This study shows mechanical tension, not just biochemical signals, actively drives cell extrusion via RhoA-mediated contractility in epithelial monolayers.
bioRxiv · Jul 8, 2026 · PreprintCell Biology