Tien Dang

Vimentin bridges scales to convert polarized cell locomotion into coordinated collective migration

This study shows vimentin enables efficient collective cell migration by converting polarized cell movement into coordinated group motion during wound healing.

Mechanical Tension Actively Triggers RhoA-Mediated Cell Extrusion

This study shows mechanical tension, not just biochemical signals, actively drives cell extrusion via RhoA-mediated contractility in epithelial monolayers.

EpCAM sustains crypt mechanics and prevents aberrant remodeling

This study identifies EpCAM as a key regulator of epithelial contractility and crypt morphogenesis, showing its role in maintaining crypt structure and preventing aberrant remodeling.

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

This study demonstrates that epithelial tissue homeostasis is maintained through active trans-epithelial fluid flow, not cell contractility, using an in vitro model of micro-sized hydrogel spheres.

Length-limitation of astral microtubules orients cell divisions in intestinal crypts

The paper shows that length-limited astral microtubules cause planar spindle orientation in intestinal crypts, independent of polarity and geometry cues.