René‐Marc Mège

The paper shows that cell division in epithelia follows a mechanical principal-stress rule rather than a geometric rule, as cells divide along their principal stress axis to relieve anisotropic stress.

This study identifies local mechanical heterogeneity as the driver of epidermal cell delamination through force balance changes and actomyosin remodeling in keratinocytes.

This study shows curvature guides chiral organization and myogenic differentiation in myoblast tissues, with handedness determined by substrate curvature.

The paper introduces a robust FRAP framework, ImpRes, to accurately quantify fast cytoplasmic diffusion by addressing noise, normalization, and spatial restrictions through a single-equation fitting approach.

This study shows vimentin enables efficient collective cell migration by converting polarized cell movement into coordinated group motion during wound healing.

This study shows mechanical tension, not just biochemical signals, actively drives cell extrusion via RhoA-mediated contractility in epithelial monolayers.

This study investigates the microscopic dynamics of cells in high-density epithelial tissues, revealing sub-diffusive creep and stress-driven fluidity despite their jammed state.

This study investigates how cytoplasmic crowding affects macromolecule diffusion using live-cell experiments and porous media modeling, finding that effective diffusivity depends on obstacle volume fraction rather than specific regions.

This study demonstrates that epithelial tissue homeostasis is maintained through active trans-epithelial fluid flow, not cell contractility, using an in vitro model of micro-sized hydrogel spheres.

This paper identifies a new mode of large-scale collective motion in epithelial cells, showing they behave as polar elastic solids with scale-free correlations and Goldstone modes, distinct from fluid-like dynamics.

This study identifies force transmission as a key factor in cell competition, showing that stronger intercellular adhesion leads to cell elimination through mechanical stress fluctuations.