Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation
Gabriela Giordano, Robin M. Buratowski, Celia Jerónimo, Christian Poitras, François Robert, Stephen Buratowski
This study uncouples the TFIIH kinase and core modules by splitting Tfb3, revealing that module coupling is necessary for localized CTD Serine 5 phosphorylation during transcription.
eLife · Jun 8, 2026Peer-reviewedMolecular Biology