Christian Poitras

Kinetic decoupling of early transcription reveals Mediator regulates paused RNA polymerase II stability

This study uncouples Mediator's role in RNAPII transcription initiation from its effects on promoter-proximal pausing, showing Mediator regulates paused RNAPII stability rather than P-TEFb recruitment.

Uncoupling the TFIIH Core and Kinase Modules Leads To Misregulated RNA Polymerase II CTD Serine 5 Phosphorylation

This study uncouples the TFIIH kinase and core modules by splitting Tfb3, revealing that module coupling is necessary for localized CTD Serine 5 phosphorylation during transcription.

Investigating pancreatic β cell membrane epitopes using unbiased cell-based Fab-phage display

This study uses Fab-phage display and bioinformatics to identify and characterize Fabs binding to pancreatic β cell membrane epitopes in a hyperglycemic environment.

HP1-enhanced chromatin compaction stabilizes a synthetic metabolic circuit in yeast

This paper shows that expressing HP1 homologues in yeast increases chromatin compaction, reducing mutation and recombination rates, and improving the stability of synthetic metabolic circuits.

High-accuracy mapping of human and viral direct physical protein-protein interactions using the novel computational system AlphaFold-pairs

The paper introduces AlphaFold-pairs, a computational method to predict protein-protein interactions, validated on human and viral systems, revealing new interactions in SARS-CoV-2 and Influenza A virus.

FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.