François Robert

This study uncouples Mediator's role in RNAPII transcription initiation from its effects on promoter-proximal pausing, showing Mediator regulates paused RNAPII stability rather than P-TEFb recruitment.

This study uncouples the TFIIH kinase and core modules by splitting Tfb3, revealing that module coupling is necessary for localized CTD Serine 5 phosphorylation during transcription.

The paper identifies NACC1 as a regulator of totipotent-like cells in mouse embryonic stem cells through a feed-forward mechanism involving gene regulation and retrotransposon activity.

This paper shows that expressing HP1 homologues in yeast increases chromatin compaction, reducing mutation and recombination rates, and improving the stability of synthetic metabolic circuits.

The paper investigates the effects of separating Mediator modules on transcription, finding that tail/cMed disconnection leads to overactivation of TFIID-dependent genes and underactivation of SAGA-requiring genes.

The paper identifies that FACT binds partially unwrapped nucleosomes in transcribed genes and spreads along genes in a Chd1-dependent manner.

This study identifies Ubp15 as a deubiquitylase that couples transcription to mRNA export by regulating the ubiquitylation of Mex67 and its interaction with THO in yeast.

The paper investigates the interaction between Cdk9, H2Bub1, and the Clr6-CII HDAC complex in regulating antisense and sense transcription in fission yeast.