Small molecules targeting ARF1 interaction with C9orf72:SMCR8:WDR41 complexes suppress its overactivation implicated in ALS/FTD
Emma K. Dixon, Fereshteh Azimian, Angelina Joby-Chacko, Rodney Tatum, Christi Boykin, Yanhua Chen, Qun Lu
This study identifies a small molecule, SCC944, that targets ARF1-CSW interactions and reduces GTP-bound ARF1, showing potential as a therapeutic for ALS/FTD.
Scientific Reports · Oct 3, 2026Peer-reviewedPharmacology & Toxicology