Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancer
Johnvesly Basappa, Cosimo Lobello, Anneliese M. Faustino, Cristina Uribe‐Alvarez, David Rushmore, Niel Sen, Li Wang, Andrey Efimov, Kathy Qi Cai, Jaime Laurel Schneider, Lori A. Rink, Aaron N. Hata, Luca Mologni, Wujuan Zhang, Aaron R. Goldman, , Mariusz A. Wasik
This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.
bioRxiv · Aug 17, 2026 · PreprintCancer Biology