Hsin‐Yao Tang

This study shows that NAD metabolism supports CTCF-cohesin chromatin regulation in EBV-transformed B-cells and identifies NAMPT inhibition as a potential therapeutic strategy.

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

This paper identifies the trypanosomatid dynamin-like protein (DLP) as associating with glycosomes and shows its role in glycosome maintenance through knockdown and overexpression experiments.

This paper identifies a pathway where dopamine induces mitochondrial dysfunction in macrophages, leading to IL-6 secretion via the cGAS-STING pathway.

This paper identifies Siglec-10/α3β1 integrin interactions as a mechanism suppressing macrophage phagocytosis in PDAC and shows that targeting these interactions enhances anti-tumor immunity.

This study shows that impaired 5'ETS pre-rRNA cleavage disrupts nucleolar organization, leading to mislocalization of RNA and proteins, and broader nuclear architecture changes.

This study shows that Mukungulu, an African medicinal plant extract, effectively reverses HIV-1 latency in humanized mice and human cells, outperforming standard controls.

The paper identifies the molecular mechanism by which human sperm mitochondria lack mtDNA and how TFAM re-localization leads to paternal mtDNA elimination.

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.

This study identifies PLOD1 as a post-translational regulator of EBNA1 protein stability and function in EBV latency, showing that PLOD1 depletion reduces EBNA1 levels and inhibits viral replication and episome maintenance.

The paper introduces SMSNet, a deep learning framework for de novo peptide sequencing that identifies thousands of new HLA antigens and phosphopeptides with high accuracy.