The genetic architecture of protein interaction affinity and specificity
Alexandra M. Bendel, André J. Faure, Dominique Klein, Kenji Shimada, Romane Lyautey, Nicole Schiffelholz, Georg Kempf, Simone Cavadini, Ben Lehner, Guillaume Diss
The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.
Nature Communications · Oct 14, 2024Peer-reviewedSystems Biology