Author

Dominique Klein

Friedrich Miescher Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

Alexandra M. BendeliD· 4 shared Guillaume DissiD· 4 shared Georg KempfiD· 3 shared Ben LehneriD· 2 shared Kenji ShimadaiD· 2 shared Simone CavadiniiD· 2 shared Alexander HanzliD· 1 shared André J. FaureiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersSystems Biology

Alexandra M. BendelORCID

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Author profile →

4 papers

Recent·Most cited

Mapping the latent CRBN-molecular glue degrader interactome

Pius Galli, Shuhao Xiao, Yanxiang Meng, Alexander Hanzl, Alexandra M. Bendel, Regina Baur, Jacob D. Aguirre, Anna M. Díaz-Rovira, Maximilian R. Stammnitz, Georg Kempf, Lukas Kater, Kenji Shimada, Ye Wei, Andreas Scheck, Dominique Klein, , Nicolas H. Thomä

The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.

Nature Biotechnology · Aug 13, 2026Peer-reviewedMolecular Biology

The genetic architecture of the human bZIP family

Alexandra M. Bendel, Bastian Eichenbergers, Georg Kempf, Dominique Klein, K. Shimada, M. Franco, S.H.W. Kraatz, Sevi Durdu, Vivian Herrmann, Grégory Roth, Charlotte Soneson, Sébastien A. Smallwood, Nicolas H Thomae, Dirk Schübeler, Michael Beda Stadler, , Guillaume Diss

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

bioRxiv · Aug 21, 2025 · PreprintBiophysics

The genetic architecture of protein interaction affinity and specificity

Alexandra M. Bendel, André J. Faure, Dominique Klein, Kenji Shimada, Romane Lyautey, Nicole Schiffelholz, Georg Kempf, Simone Cavadini, Ben Lehner, Guillaume Diss

The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.

Nature Communications · Oct 14, 2024Peer-reviewedSystems Biology

Optimization of a deep mutational scanning workflow to improve quantification of mutation effects on protein-protein interactions

Alexandra M. Bendel, Kristjana Skendo, Dominique Klein, Kenji Schimada, Kotryna Kauneckaite-Griguole, Guillaume Diss

The paper optimizes a deep mutational scanning workflow to reduce non-linearities in quantifying mutation effects on protein-protein interactions.

BMC Genomics · Jun 24, 2024Peer-reviewedSystems Biology