Author

Nicole Schiffelholz

Friedrich Miescher Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexandra M. BendeliD· 1 shared André J. FaureiD· 1 shared Attila BecskeiiD· 1 shared Ben LehneriD· 1 shared Dominique Klein· 1 shared Georg KempfiD· 1 shared Guillaume DissiD· 1 shared Kenji ShimadaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Alexandra M. BendelORCID

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2 papers

Recent·Most cited

Heat shock induces silent ribosomes and reorganizes mRNA turnover

Sayanur Rahaman, Nicole Schiffelholz, Nitish Mittal, Klemens Fröhlich, Mihaela Zavolan, Attila Becskei

The paper shows heat shock increases silent ribosomes and reorganizes mRNA turnover in yeast by prioritizing heat-shock protein synthesis over ribosome biogenesis.

Cell Reports · Oct 1, 2025Peer-reviewedGenomics

The genetic architecture of protein interaction affinity and specificity

Alexandra M. Bendel, André J. Faure, Dominique Klein, Kenji Shimada, Romane Lyautey, Nicole Schiffelholz, Georg Kempf, Simone Cavadini, Ben Lehner, Guillaume Diss

The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.

Nature Communications · Oct 14, 2024Peer-reviewedSystems Biology