Simone Cavadini

The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.

This study shows that SERDs induce ER SUMOylation, which recruits co-repressors to suppress transcription, rather than relying on ER degradation for their activity.

The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.

The paper develops qPISA to quantify protease substrate turnover, revealing subsite cooperativity in DPP4 and distinguishing it from DPF-3.

GUIFold provides a user-friendly interface for AlphaFold2, enabling job tracking, submission, and prediction evaluation without technical expertise.