Guillaume Diss

The paper identifies CRBN-pomalidomide binders using a combination of GluePCA and AI-derived protein surface queries, revealing known and novel interactors for MGD development.

The paper systematically mutagenizes human bZIP domains and uses deep mutational scanning to quantify interactions, revealing complex genetic architecture and enabling synthetic bZIP design.

The paper quantifies how mutations in JUN affect its binding to 54 human basic leucine zipper transcription factors, revealing that specificity is encoded by both positive and negative determinants.

The paper optimizes a deep mutational scanning workflow to reduce non-linearities in quantifying mutation effects on protein-protein interactions.

mutscan provides an R package for end-to-end analysis of MAVE data, supporting statistical modeling and visualization of variant effects.