Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis
Carmen G. Palii, Steven Tur, Sirui Yan, William J.R. Longabaugh, Romeo Solano, Francis Jeffrey Dilworth, Jeffrey A. Ranish, Marjorie Brand
The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.
bioRxiv · Sep 11, 2025 · PreprintGenomics