Marjorie Brand

This study shows that YY1 REPO domain regulates TET2 expression, which is essential for T cell development, and that disrupting this regulation causes developmental defects.

The paper establishes dynamic enhancer-based gene regulatory networks in human hematopoiesis, revealing that stemness loss and lineage acquisition are temporally and mechanistically uncoupled.

QuickProt provides Python-based Colab notebooks for analyzing DIA and PRM proteomics data, enabling quality control, visualization, and interpretation without coding expertise.

The paper identifies CAD-bound genes involved in both muscle cell differentiation and cancer-causing translocations, showing CAD-induced breaks are physiologic in differentiation and linked to oncogenic gene regulation.

This study shows Pten and Dscam regulate amacrine cell spacing through endocytic trafficking of cell adhesion and signaling molecules, with altered extracellular vesicles and Wnt signaling in Pten mutants.

The paper quantifies transcription factor abundances during human erythropoiesis and reveals gene regulatory principles and imbalances in coactivator-corepressor ratios.

This study models erythropoiesis in CDA-I by analyzing patient-derived erythroblasts, identifying abnormalities in DNA accessibility, proliferation, and enucleation, with genotype-phenotype correlations.

This study shows that EHMTs regulate heterochromatin anchoring to the nuclear periphery via LaminB1 methylation and reveals their role in aging-related nuclear changes.